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October 08, 2007

The Secret History Of The War On Cancer Corporations, Globalization  Ethics  Science/Technology

Over the weekend, I picked up a new book called The Secret History of the War on Cancer by Devra Davis, an epidemiologist who heads the Center for Environmental Oncology at the University of Pittsburgh. It looked like something I'd want to write about on the blog, but who knows how soon I'll get to it. So many books, so little time. But today, Salon comes to the rescue with a review and interview. This is a long excerpt, but it's important:

Davis, who is a professor of epidemiology at the University of Pittsburgh Graduate School of Public Health and formerly served in the U.S. Department of Health and Human Services, argues that the United States' $40 billion "war on cancer" has focused far too much on treatment, and not nearly enough on prevention....For instance, in the late '60s, three years after the surgeon general declared that smoking causes cancer, the United States spent $30 million of taxpayer money to create a safer cigarette, essentially doing the tobacco companies' research and development for them. Needless to say, this effort failed, but it succeeded in giving the tobacco companies cover, assuring smokers that a safer cigarette was just around the corner.

Davis argues that again and again, from tobacco to benzene to asbestos, the profit motive has trumped concerns about public health, delaying, sometimes for decades, the containment of avoidable hazards. And, as in the current scientific "debate" about global warming, the legitimate need for ongoing scientific research about many possible carcinogens has been exploited by industry to promote the idea that there's really no need to worry.

In "The Secret History of the War on Cancer," we meet one of the foremost epidemiologists of the 20th century, who is revealed after his death to have been on the take from Monsanto to the tune of $1,500 a day, and we visit the site of former towns that have literally disappeared, like Times Beach, Mo., which since being declared a toxic waste site, has been incinerated, reduced to some grass, geraniums and tulips -- the only signs that anyone ever once lived there. [...]

Salon: In the U.S., one out of every two men and one out of every three women will develop cancer in their lifetimes....Testicular cancer in men under age 40 has risen 50 percent in a decade. What are the theories about why there might be such a radical increase?

Davis: In the United States and Japan, there has been a significant decline in the birth of baby boys. What does this have to do with testicular cancer? Well, there's a theory of testicular dysgenesis, which means that there is something on the Y chromosome that is transmitted to boys that is affecting their overall health, and it may affect whether or not a boy sperm works to fertilize an egg...And these things are likely to be related to early life exposures to hormone-mimicking chemicals....There's recently been a report from the Arctic Assessment of many more girls than boys being born. If something is affecting such an exquisitely sensitive part of human biology, then what else is it doing to us?

Salon: When we read about a study that says XYZ substance causes cancer in rats, how should we interpret it?

Davis: We differ from rodents by about 300 genes. That's it. The differences aren't nearly as big as some people would like you to think.

We use animal research to develop drugs. But when it comes to evidence that something causes cancer in an animal, something that might be used in our schools and homes, we say: "Well, wait. We better get proof of human harm." How can we say that we'll rely on animal studies when we're trying to invent drugs, and then deny their relevance to us when we're trying to predict, and prevent, human harms?

Salon: What's the alternative?

Davis: The alternative is to do experiments on people, or worse, which is what we are doing -- a vast uncontrolled experiment. We will never be able to answer many of these questions, because there is no control group. Who isn't exposed to cellphones? Who isn't exposed to aspartame? Who's not exposed to solar radiation? And that makes it very difficult to do studies of human health consequences. It really does. [...]

Salon: Why do you have concerns about aspartame, the artificial sweetener in many soft drinks and other low-calorie foods? [...]

Davis: In 1977, Richard Merrill, who later became dean of the University of Virginia Law School, was the chief counsel of the Food and Drug Administration, and he formally asked the U.S. attorney to convene a grand jury to decide whether or not to indict the producer of aspartame, G.D. Searle, for misrepresenting "findings, concealing material facts and making false statements" in aspartame safety tests.

This is not some left-wing group. This is the actual chief counsel of the FDA asking the U.S. attorney's office to convene a grand jury. It never happened, because by the time the grand jury was ready to be convened we had a new president. That president was Reagan, and within a month of Reagan taking office, he had a proposal from a guy you might have heard of named Donald Rumsfeld [who was then chief operating officer of Searle].

And Jan. 22, 1981, one day after Reagan's inauguration -- one day -- Searle reapplied for FDA approval. Prior to that, every single request for approval was turned down by all the scientists ever looking at the data. That's a fact. There's no dispute about that fact. And then, it gets approved May 19, 1981.

Remember what happened with the Reagan revolution? It was: "We need to get the government off our backs." One of the backs it got off of was suppressing the aspartame industry. Later, many of the people who worked at the FDA to evaluate aspartame ended up going to work for the company producing it. [...]

The thing that I'm most concerned about is the latest study from Italy. A typical rat study runs two years; that would be getting your rat to about my age: 60. People live now to their 90s. This study started their exposure when they were babies, like what we do now in the United States with aspartame, and let the rats live out their natural lifetimes until they were 3 years old.

And when they did that they found a significant increase in tumors that occurred only in that third year of life. Of course, the European Food Safety Authority, which sounds very independent, says the study is worthless. But I looked up the background on the people involved with the European Food Safety Authority, and many of them work directly for the food industry.

The Ramazzini Foundation, a toxicology institute, which did the study, is not known to be radical. Unlike most other sources of information in toxicology, it's truly independent. It is not funded by Monsanto. And what they found is that there is significant increase in lymphomas and leukemia, and that the increase comes not from consuming 800 cans of soda a day, but from consuming fairly moderate amounts of aspartame in these animals' lifetimes. They had 1,800 animals, and some of them were just consuming the equivalent of two cans of soda a day, two yogurts, 10 pieces of chewing gum. And at that level of consumption, there was a significant increase in cancer, and it only showed up in older rats.

Salon: How have recent court rulings made it harder to try to prevent cancer?

Davis: We have gone backward since the '70s. In the '70s, in the decision on lead in gasoline, the court said we could use experimental evidence that something was a threat to human health in order to prevent harm. The court repeatedly ruled that the Environmental Protection Agency could use theories, models and estimates to prevent harm.

Now, we have to prove that harm has already happened before taking action to prevent additional harm. In the area of cancer this is a travesty, since most cancer in adults takes five, 10, 20 or 30 years [to develop]. It means that we have no opportunity to prevent cancer, because we must prove through human evidence that it's already happened....Ninety percent of all claims now for toxic torts are denied. [...]

I'm very, very concerned about the overuse of diagnostic radiation, especially in children. For example, CT scans [CAT scans] of the head and the abdomen. Now, obviously if you have a child with a potentially fatal head injury or a stomach bleed, you can use a CT scan.

Most people don't realize that a CT scan to the head of a baby can give you between 200 and 4,000 chest X-rays at once. And therefore they should be used in a much more limited way. And guess who agrees with me? The American College of Radiology has called for reducing the use of diagnostic radiation in children. [...]

[P]olar bears in the Arctic are showing up as hermaphrodites with toxic waste in their bodies that would qualify them for burial in a hazardous waste site. How do you think that they're getting exposed to these pollutants? They don't work at factories. But they are at the top of the polar food chain, and pollutants go up through the food chain stored in fat from the little fish to the big fish to the walrus to the polar bear. Ultimately, they're making it very clear that pollutants don't need passports, and that you can't ban toxic materials in one nation. It has to be a global policy. [...]

I've developed a theory of Xeno estrogen, named for the Greek word for "foreign." Basically, all of the risk factors that have been identified for breast cancer, except radiation, are related to the total lifetime exposure to hormones. So, the earlier in life you get your period and the later in life you go through menopause, the more hormones you're exposed to in your lifetime, and the greater your risk of breast cancer. The more alcohol you drink in your lifetime -- alcohol is highly estrogenic -- the greater your risk of breast cancer. The less exercise you get -- exercise lowers the amount of circulating estrogen -- the more estrogen in your life. The more fat in your body, the more estrogen, because fat is estrogenic. [...]

Why are more young girls going into puberty at an earlier age? Why are more young girls developing breasts? There are several reasons to think that hormones in personal care products may be playing a role, particularly for breast cancer in young black women.

Some black baby girls were found to have breasts between ages 1 and 3, and when Dr. Chandra Tiwary, who was a pediatric endocrinologist with the Air Force at Brooks Air Force Base, interviewed the mothers he found out the mothers were all putting a cream on the girls' scalps. And we don't know what the hell for sure was in all those creams then, but Dr. Tiwary found when the mother stopped using the cream, the breasts went away.

If something is making the breasts grow in a baby, what is it doing to others in terms of promoting growth at the wrong time, or promoting an improper or excessive amount of breast growth that could lead to cancer?

Salon: Why are you concerned about cellphones?

Davis: I can't tell you that cellphones are safe, and I can't tell you that they are harmful. That's the problem. The reason I can't is that there isn't really independent information, and the cellphone industry has been so quick to spin information.

Studies that you hear about that don't find a risk are often extremely limited, like the Danish Cancer Study. That's a ridiculous study. Anybody who used a cellphone for work was kicked out of the study, which is crazy, because those are the highest users. And they put all of these people together who were not using it for business -- the high users, the low users -- and they didn't find anything.

A study just released from France showed that people who used a cellphone for 10 or more years have double the risk of brain cancer. And people who owned two or more cellphones had more than double the risk of brain cancer. The level of this increase wasn't what we call statistically significant, but that doesn't mean that it wasn't important. [Emphasis added]

Something I've been thinking about a lot lately is the way we all hear things that ought to fundamentally adjust our way of thinking about the world, but with all the other input that's flooding our attention, most of it utterly trivial, the important thing soon fades from awareness. It's not forgotten exactly, but it's no longer in the foreground, and it's certainly not acted on.

For example. We all know that cigarette companies worked for decades to suppress information linking smoking and cancer. But we don't fully take on board the implications. These actions were taken by ordinary human beings in a corporate setting. The group-think and peer pressure of the workplace, the desire to get ahead or even just to put food on the table, the boundless human capacity for denial and rationalization, these things were enough to cause ordinary people to conspire in activities that killed many thousands of their company's customers. But here's the thing: there was nothing special about tobacco companies. Any number of modern corporations have similar internal dynamics, with similar results. So we shouldn't be surprised to learn that any number of other corporations have knowingly downplayed or falsified information about the harmful effects of their products. This is what happens when you have powerful institutions whose sole guiding principle is to maximize profit. The tobacco company story is repeated over and over again. Connect the dots.

Posted by Jonathan at October 8, 2007 09:45 PM  del.icio.us digg NewsVine Reddit YahooMyWeb

Comments

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Posted by: Sue at October 14, 2007 11:44 PM